Mechanisms by which circadian rhythm disruption may lead to cancer

Mechanisms by Which Dehydration May Lead to Chronic Kidney Disease.

Dehydration, a condition that characterizes excessive loss of body water, is well known to be associated with acute renal dysfunction; however, it has largely been considered reversible and to be associated with no long-term effects on the kidney. Recently, an epidemic of chronic kidney disease has emerged in Central America in which the major risk factor seems to be recurrent heat-associated d...

Circadian rhythm disruption in cancer biology.

Circadian rhythms show universally a 24-h oscillation pattern in metabolic, physiological and behavioral functions of almost all species. This pattern is due to a fundamental adaptation to the rotation of Earth around its own axis. Molecular mechanisms of generation of circadian rhythms organize a biochemical network in suprachiasmatic nucleus and peripheral tissues, building cell autonomous cl...

Circadian rhythm disruption exists in icu patients

Introduction Circadian rhythms, which are generated by autonomous clock genes called peripheral oscillators, has a pivotal role in harmonising the function of organs and cells of the human body, while disruption of these rhythms (i.e. chronodisruption) is accompanied with a wide spectrum of health disorders. Circadian rhythms in healthy subjects are orchestrated by the dark-time elevation of me...

Sleep and circadian rhythm disruption in schizophrenia†

BACKGROUND Sleep disturbances comparable with insomnia occur in up to 80% of people with schizophrenia, but very little is known about the contribution of circadian coordination to these prevalent disruptions. AIMS A systematic exploration of circadian time patterns in individuals with schizophrenia with recurrent sleep disruption. METHOD We examined the relationship between sleep-wake acti...

Disruption of Circadian Rhythm in Mice Increases Susceptibility to Osteoarthritis